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ag879  (MedChemExpress)
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Chemical structures of RTK inhibitors <t>AG879,</t> Lapatinib, Gefitinib, and GW441756 ( A ). Timeline of infection, treatment, and viral collection ( B ). SARS-CoV-2 replication in cells pre-treated with RTK inhibitors. A549-ACE2 (top panels) and Vero-E6 (bottom panels) were treated for 30 min and then infected with SARS-CoV-2 (WA1) at an MOI = 0.01. Supernatants were collected, and viral particles were quantified by measuring viral RNA via RT-qPCR ( C ) and infectious particles via a plaque assay ( D ). Viral RNA levels in the infected cells were quantified by RT-qPCR ( E ). ns, p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.
Ag879, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ag879/Tyrphostin+AG+879/pmc12030552-42-0-1
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ag879  (Molecular Dynamics Inc)
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Molecular Dynamics Inc ag879
Chemical structures of RTK inhibitors <t>AG879,</t> Lapatinib, Gefitinib, and GW441756 ( A ). Timeline of infection, treatment, and viral collection ( B ). SARS-CoV-2 replication in cells pre-treated with RTK inhibitors. A549-ACE2 (top panels) and Vero-E6 (bottom panels) were treated for 30 min and then infected with SARS-CoV-2 (WA1) at an MOI = 0.01. Supernatants were collected, and viral particles were quantified by measuring viral RNA via RT-qPCR ( C ) and infectious particles via a plaque assay ( D ). Viral RNA levels in the infected cells were quantified by RT-qPCR ( E ). ns, p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.
Ag879, supplied by Molecular Dynamics Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ag879/ag879/pm37114656-258-6-0
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ag879 (csa no. 148741-30-4)  (Cayman Chemical)
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Cayman Chemical ag879 (csa no. 148741-30-4)
Chemical structures of RTK inhibitors <t>AG879,</t> Lapatinib, Gefitinib, and GW441756 ( A ). Timeline of infection, treatment, and viral collection ( B ). SARS-CoV-2 replication in cells pre-treated with RTK inhibitors. A549-ACE2 (top panels) and Vero-E6 (bottom panels) were treated for 30 min and then infected with SARS-CoV-2 (WA1) at an MOI = 0.01. Supernatants were collected, and viral particles were quantified by measuring viral RNA via RT-qPCR ( C ) and infectious particles via a plaque assay ( D ). Viral RNA levels in the infected cells were quantified by RT-qPCR ( E ). ns, p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.
Ag879 (Csa No. 148741 30 4), supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ag879/ag879++csa+no++148741+30+4+/pm37114656-28-13-20
Average 90 stars, based on 1 article reviews
ag879 (csa no. 148741-30-4) - by Bioz Stars, 2026-10
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ag879  (Tocris)
90
Tocris ag879
Chemical structures of RTK inhibitors <t>AG879,</t> Lapatinib, Gefitinib, and GW441756 ( A ). Timeline of infection, treatment, and viral collection ( B ). SARS-CoV-2 replication in cells pre-treated with RTK inhibitors. A549-ACE2 (top panels) and Vero-E6 (bottom panels) were treated for 30 min and then infected with SARS-CoV-2 (WA1) at an MOI = 0.01. Supernatants were collected, and viral particles were quantified by measuring viral RNA via RT-qPCR ( C ) and infectious particles via a plaque assay ( D ). Viral RNA levels in the infected cells were quantified by RT-qPCR ( E ). ns, p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.
Ag879, supplied by Tocris, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ag879/ag879/pm38203377-156-8-11
Average 90 stars, based on 1 article reviews
ag879 - by Bioz Stars, 2026-10
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Chemical structures of RTK inhibitors AG879, Lapatinib, Gefitinib, and GW441756 ( A ). Timeline of infection, treatment, and viral collection ( B ). SARS-CoV-2 replication in cells pre-treated with RTK inhibitors. A549-ACE2 (top panels) and Vero-E6 (bottom panels) were treated for 30 min and then infected with SARS-CoV-2 (WA1) at an MOI = 0.01. Supernatants were collected, and viral particles were quantified by measuring viral RNA via RT-qPCR ( C ) and infectious particles via a plaque assay ( D ). Viral RNA levels in the infected cells were quantified by RT-qPCR ( E ). ns, p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.

Journal: Pathogens

Article Title: Cellular Receptor Tyrosine Kinase Signaling Plays Important Roles in SARS-CoV-2 Infection

doi: 10.3390/pathogens14040333

Figure Lengend Snippet: Chemical structures of RTK inhibitors AG879, Lapatinib, Gefitinib, and GW441756 ( A ). Timeline of infection, treatment, and viral collection ( B ). SARS-CoV-2 replication in cells pre-treated with RTK inhibitors. A549-ACE2 (top panels) and Vero-E6 (bottom panels) were treated for 30 min and then infected with SARS-CoV-2 (WA1) at an MOI = 0.01. Supernatants were collected, and viral particles were quantified by measuring viral RNA via RT-qPCR ( C ) and infectious particles via a plaque assay ( D ). Viral RNA levels in the infected cells were quantified by RT-qPCR ( E ). ns, p > 0.05; *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001.

Article Snippet: AG879 (MedChemExpress, HY-20878, Monmouth Junction, NJ, USA) is a selective inhibitor of both tropomyosin kinase receptor A (TrkA) and human epidermal growth factor receptor 2 (HER2), Lapatinib (Sigma Aldrich, CDS022971, St. Louis, MO, USA) is a reversible inhibitor of both epidermal growth factor receptor (EGFR) and HER2, Gefitinib (Sigma Aldrich, SML1657) is a selective inhibitor of EGFR, and GW441756 (MedChemExpress, HY-18314) is a selective inhibitor of TrkA [ , , ].

Techniques: Infection, Quantitative RT-PCR, Plaque Assay